作者：Bo Lin;Shihua Xiang;Mengsen Li （1 Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou 571199, Hainan, China 2 Institution of Tumor, Hainan Medical College, Haikou 570102, Hainan, China 3 Nebraska Center for Virology, School of Veterinary Medicine and Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA）

出处：Marine Drugs 2016

关键词：  α  conotoxins;Ac  AChBP;design;model;nAChRs;X  ray structure  

摘要：Nicotinic acetylcholine receptors (nAChRs) are targets for developing new drugs to treat severe pain, nicotine addiction, Alzheimer disease, epilepsy, ...

作者：Yan Lu, Kaiqing Hou, Mengsen Li, Xiaobin Wu, Shaochun Yuan （Affiliations 1 Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Key Laboratory of Gene Engineering of the Ministry of Education, College of Life Sciences, Sun Yat-sen University, Guangzhou, China. 2 Department of Gastrointestinal Surgery, The 8th Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. 3 Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou, China. 4 Department of Gastrointestinal Surgery, Haikou City People\'s Hospital, Haikou, China.）

出处：Frontiers in cell and developmental biology 2020

关键词：  EZH2;GSDME;exosome;gastric cancer;lncHEIH.  

摘要：Gastric cancer is the third leading cause of cancer-related deaths worldwide and is characterized by poor survival and high recurrence rates. Long non ...

作者：Mengsen Li;Mingyue Zhu;Wei Li;Yan Lu;Xieju Xie;Yuqiang Wu;Shaojiang Zheng; （1 Key Laboratory of Molecular Biology, Hainan Medical College, Haikou 571199, China 2 Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou 571199, China 3 Department of Pathophysiology, Hainan Medical College, Haikou 571199, China 4 Department of Hepatobiliary Surgery, Hainan Province People Hospital, Haikou 570232, China 5 Department of Pathology, Hainan Medical College, Haikou 571199, China）

出处：Cancer Letters 2013

关键词：  Alpha  fetoprotein receptor;Hepatitis B virus x protein;Hepatocellular carcinoma;Cancer cell metastasis  

摘要：AFP and its receptor (AFPR) are early indicators of HBx-driven hepatocarcinogenesis. Clinical specimens, normal human liver cells L-02 and HCC cell li ...

作者：Yan Lu;Yan Lu;Yan Lu;Kaiqing Hou;Mengsen Li;Xiaobin Wu;Shaochun Yuan （Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Key Laboratory of Gene Engineering of the Ministry of Education, College of Life Sciences, Sun Yat-sen University, Guangzhou, China Department of Gastrointestinal Surgery, The 8th Affiliated Hospital of Sun Yat-sen University, Shenzhen, China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou, China Department of Gastrointestinal Surgery, Haikou City People’s Hospital, Haikou, China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou, China Department of Gastrointestinal Surgery, The 8th Affiliated Hospital of Sun Yat-sen University, Shenzhen, China Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, Key Laboratory of Gene Engineering of the Ministry of Education, College of Life Sciences, Sun Yat-sen University, Guangzhou, China）

出处：Frontiers in Cell and Developmental Biology 2020

关键词：  exosome;lncHEIH;EZH2;GSDME;gastric cancer  

摘要：Gastric cancer is the third leading cause of cancer-related deaths worldwide and is characterized by poor survival and high recurrence rates. Long non ...

作者：朱明月，郭峻莉，夏华，李伟，鲁琰，董栩，陈栘，符史干，谢协驹，李孟森 （海南医学院海南省肿瘤发生和干预重点实验室；海南医学院分子生物学重点实验室；广西医科大学研究生学院；海南医学院病理生理学教研室；海南医学院肿瘤研究所）

出处：中华肝脏病杂志 2014

关键词：  癌,肝细胞；甲胎蛋白；耐药；PI3K/AKT信号通路；全反式维甲酸  

摘要：目的研究甲胎蛋白(AFP)对肝癌细胞内PI3K/AKT信号传递的影响,以及其在癌细胞耐受全反式维甲酸(ATRA)中的作用。方法四甲基偶氮唑盐(MTT)法检测ATRA对人肝癌Bel7402细胞增殖的影响;显微照相观察细胞形态学的改变;流式细胞分析细胞凋亡;激光共聚焦显微镜观察AFP与PTEN的共定位; ...

作者：李孟森，李平风，李刚，杜国光（海南医学院生物化学教研室；北京大学医学部生物化学与分子生物学系） （海南医学院生物化学教研室；北京大学医学部生物化学与分子生物学系）

出处：生物化学与生物物理学报 2002

关键词：  甲胎蛋白  细胞增殖  信号转导  基因表达  

摘要：為探討甲胎蛋白(alpha-fetoprotein，AFP)對腫瘤細胞增殖的促進作用。用從人臍帶血中提取的AFP作用於體外培養的HeLa細胞，通過MTT計數、[(上標 3)H]-TdR參入法、流式細胞儀等研究細胞增殖，並用放射免疫法測定細胞內cAMP、共聚焦顯微鏡掃描細胞內Ca(上標2+)濃度等觀察 ...

作者：Mengsen Li;Sheng Zhou;Xinhua Liu;Pingfeng Li;Michael A McNutt;Gang Li （Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, 100083, China Laboratory of Analysis Chemistry, Hainan Medical College, Hainan 571101, China Department of Pathology, Peking University Health Science Center, Beijing, 100083, China Center of Infectious Disease, Peking University, Beijing, 100083, China）

出处：Cancer Letters 2007

关键词：  α  fetoprotein;Apoptosis;Caspase  3;Tumor necrosis factor  related apoptosis  inducing ligand  

摘要：The interference of α-fetoprotein (AFP) with the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in Bel 7402 cell ...

作者：Meng-Sen Li;Qiu-Ling Ma;Qian Chen;Xin-Hua Liu;Ping-Feng Li;Guo-Guang Du;Gang Li （; 1 Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China ; 2 Hainan Med Coll, Dept Biochem, Haikou 571101, Hainan Province, Peoples R China）

出处：World journal of gastroenterology : WJG 2005

摘要：AIM: To investigate the mechanism of alpha-fetoprotein (AFP) in escaping from the host immune surveillance of hepatocellular carcinoma. METHODS: AFP p ...

作者：李孟森;李平风;李刚;杜国光 （[ 1 ] Hainan Med Coll, Dept Biochem, Haikou 571101, Peoples R China Hainan Medical University [ 2 ] Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China Peking University）

出处：ACTA BIOCHIMICA ET BIOPHYSICA SINICA 2002

关键词：  PROTEIN  KINASE;CALCIUM;EVENTS;TUMOR;ACID  

摘要：A lot of investigations showed that alpha-fetoprotein(AFP) could regulate the proliferation of tumors or neoplastic cells. In order to study the enhan ...

作者：董栩，林波，李伟，朱明月，陈栘，刘坤，徐海霞，李孟森

关键词：  ①Visfatin；②GSK  3β；③肝癌细胞Bel7402  

摘要：烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD)是生物细胞内一种重要的辅酶,可直接参与呼吸链电子传递而影响细胞能量稳态,同时也可作为多种酶促反应的底物而调节NAD依赖型酶的催化活性(如SIRT1-7)。SIRT1(Sirtuin 1)通过靶向染色质组 ...